An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway
نویسندگان
چکیده
منابع مشابه
Bax regulates neuronal Ca2+ homeostasis.
Excessive Ca(2+) entry during glutamate receptor overactivation ("excitotoxicity") induces acute or delayed neuronal death. We report here that deficiency in bax exerted broad neuroprotection against excitotoxic injury and oxygen/glucose deprivation in mouse neocortical neuron cultures and reduced infarct size, necrotic injury, and cerebral edema formation after middle cerebral artery occlusion...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2016
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2016.06.010